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A Three‐Component Condensation for the Construction of the Spiro[indoline‐3,3′‐piperidin]‐2‐one Skeleton
Author(s) -
Yang HaiBin,
Guan XiaoYang,
Wei Yin,
Shi Min
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200185
Subject(s) - indoline , chemistry , dimethyl acetylenedicarboxylate , component (thermodynamics) , pyridine , condensation , skeleton (computer programming) , acetylenedicarboxylate , organic chemistry , medicinal chemistry , cycloaddition , catalysis , thermodynamics , physics , computer science , programming language
Treatment of pyridine and dimethyl acetylenedicarboxylate derivatives with N ‐substituted isatylidene derivatives resulted in three‐component condensations, affording 1′,9a′‐dihydrospiro[indoline‐3,2‐quinolizin]‐2‐one derivatives in high yields and with good diastereoselectivities through 1,4‐dipolar cycloadditions.