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Buchwald–Hartwig Coupling/Michael Addition Reactions: One‐Pot Synthesis of 1,2‐Disubstituted 4‐Quinolones from Chalcones and Primary Amines
Author(s) -
Fei XiangDong,
Zhou Zhou,
Li Wen,
Zhu YongMing,
Shen JingKang
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200172
Subject(s) - chemistry , dehydrogenation , catalysis , michael reaction , primary (astronomy) , yield (engineering) , ligand (biochemistry) , combinatorial chemistry , medicinal chemistry , organic chemistry , coupling reaction , one pot synthesis , biochemistry , physics , materials science , receptor , astronomy , metallurgy
The Buchwald–Hartwig coupling/Michael addition sequence has been successfully applied to the synthesis of functionalized 1,2‐disubstituted 4‐quinolones using Pd(OAc) 2 as a catalyst and PPh 3 as a ligand. Under these conditions, the intermediate products first formed from chalcones and primary amines underwent catalytic dehydrogenation to yield the 1,2‐disubstituted 4‐quinolones.