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Palladium‐Catalyzed Amidation and Amination of 8‐Iodopurine
Author(s) -
Chevot Franciane,
Vabre Roxane,
Piguel Sandrine,
Legraverend Michel
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200168
Subject(s) - chemistry , amination , palladium , catalysis , aryl , combinatorial chemistry , alkyl , sulfone , acetal , organic chemistry
The synthesis of 8‐amido‐ and 8‐aminopurines by a single palladium‐catalyzed protocol is reported. The method proceeds efficiently and tolerates a wide range of amides and amines as coupling partners, including aryl, alkyl, sulfone, and acetal amides, as well as deactivated m ‐ and p ‐nitroanilines. In this way, a library of new 6,8,9‐trisubstituted purines has been synthesized.
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