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In Situ Dearomatisation/Alkylation of Arylphosphane Derivatives
Author(s) -
Stankevič Marek,
Wójcik Karolina,
Jaklińska Magdalena,
Pietrusiewicz K. Michał
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200096
Subject(s) - chemistry , boranes , alkylation , halide , alkyl , in situ , organic chemistry , birch reduction , medicinal chemistry , catalysis , boron
The dearomatisation of aryldialkylphosphane–boranes and aryldialkylphosphane oxides under Birch reduction conditions, followed by treatment with reactive alkyl halides, provides the corresponding α‐functionalised (cyclohexa‐1,4‐dien‐3‐yl)phosphane derivatives. This reaction offers a method of choice for the synthesis of bulky (cyclohexadienyl)phosphanes.