Microwave‐Assisted Domino Benzannulation of α‐Oxo Ketenes: Preparation of 1,3‐Dihydro‐2 H ‐1,5‐benzodiazepin‐2‐ones | Zendy

Castillo JuanCarlos | Zendy; Presset Marc | Zendy; Abonia Rodrigo | Zendy; Coquerel Yoann | Zendy; Rodriguez Jean | Zendy

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Microwave‐Assisted Domino Benzannulation of α‐Oxo Ketenes: Preparation of 1,3‐Dihydro‐2 H ‐1,5‐benzodiazepin‐2‐ones

Author(s) -

Castillo JuanCarlos,

Presset Marc,

Abonia Rodrigo,

Coquerel Yoann,

Rodriguez Jean

Publication year - 2012

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201200093

Subject(s) - chemistry , domino , intramolecular force , microwave irradiation , derivative (finance) , nucleophile , diazo , microwave , sequence (biology) , combinatorial chemistry , stereochemistry , wolff rearrangement , medicinal chemistry , photochemistry , organic chemistry , catalysis , biochemistry , physics , quantum mechanics , financial economics , economics

The microwave irradiation of a series of 2‐diazo‐1,3‐diketones in the presence of an o ‐phenylenediamine derivative triggered a domino Wolff rearrangement/nucleophilic addition/intramolecular imination sequence to provide a new synthetic entry to 1,3‐dihydr‐2 H ‐1,5‐benzodiazepin‐2‐ones, a class of molecules with important biological properties.

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