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Discovery of Dipeptide‐Derived Catalysts for the Enantioselective Addition of Dimethylzinc to Aldehydes
Author(s) -
Kang Seock Yong,
Park Yong Sun
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200063
Subject(s) - dimethylzinc , chemistry , enantioselective synthesis , dipeptide , catalysis , yield (engineering) , organic chemistry , combinatorial chemistry , amino acid , biochemistry , materials science , metallurgy
A new class of modular chiral catalysts derived from various amino acid‐ L ‐Pro dipeptides was prepared, and the catalysts were tested for their ability to catalyze the enantioselective addition of dimethylzinc to aromatic aldehydes. Dipeptides derived from L ‐Asp‐ L ‐Pro were identified as effective catalysts for the addition at room temperature with up to 97:3 er and 95 % yield.