Discovery of Dipeptide‐Derived Catalysts for the Enantioselective Addition of Dimethylzinc to Aldehydes | Zendy

Kang Seock Yong | Zendy; Park Yong Sun | Zendy

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Discovery of Dipeptide‐Derived Catalysts for the Enantioselective Addition of Dimethylzinc to Aldehydes

Author(s) -

Kang Seock Yong,

Park Yong Sun

Publication year - 2012

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201200063

Subject(s) - dimethylzinc , chemistry , enantioselective synthesis , dipeptide , catalysis , yield (engineering) , organic chemistry , combinatorial chemistry , amino acid , biochemistry , materials science , metallurgy

A new class of modular chiral catalysts derived from various amino acid‐ L ‐Pro dipeptides was prepared, and the catalysts were tested for their ability to catalyze the enantioselective addition of dimethylzinc to aromatic aldehydes. Dipeptides derived from L ‐Asp‐ L ‐Pro were identified as effective catalysts for the addition at room temperature with up to 97:3 er and 95 % yield.

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