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Convergent Preparation of DimLe x Hexasaccharide Analogues (Eur. J. Org. Chem. 34/2011)
Author(s) -
Hendel Jenifer L.,
Auzanneau FranceIsabelle
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201190097
Subject(s) - chemistry , residue (chemistry) , stereochemistry , cover (algebra) , biochemistry , mechanical engineering , engineering
The cover picture shows an artist's impression of colorectal cancer cells displaying the tumor‐associated carbohydrate antigen dimeric Le x (dimLe x ). This hexasaccharide can be targeted for the development of anticancer vaccines that will help the immune system to selectively distinguish cancerous cells (Foe) from noncancerous cells (Friend). An analogue of the dimLe x hexasaccharide in which a galactosyl residue was replaced by a glucose unit was prepared. This analogue will be used in the preparation of such a vaccine candidate. This cover picture was designed and produced by Dr. Uwe Oehler, Department of Chemistry, University of Guelph, Ontario, Canada. Details of this work are described in the article by J. L. Hendel and F.‐I. Auzanneau on p. 6864 ff.