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Convenient Synthesis and Evaluation of a Heptadentate Bifunctional Ligand for Radioimmunotherapy Applications (Eur. J. Org. Chem. 33/2011)
Author(s) -
Chong HyunSoon,
Sun Xiang,
Dong Pengfei,
Kang Chi Soo
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201190094
Subject(s) - bifunctional , chemistry , ligand (biochemistry) , combinatorial chemistry , radioimmunotherapy , stereochemistry , monoclonal antibody , organic chemistry , antibody , biochemistry , receptor , immunology , biology , catalysis
The cover picture shows the phase contrast image of colon cancer cells (HT29) taken by a confocal microscope as the background image. Bifunctional ligands are an essential component in the biomedical and radiopharmaceutical application of biologically active metals as cytotoxic agents or imaging probes. We herein present the efficient synthesis and evaluation of the bifunctional ligand C ‐NE3TA for antibody‐targeted radiation cancer therapy. The synthetic methods to construct the bifunctional ligand are centered on the regiospecific ring opening of aziridine and the aziridinium cation. Details are discussed in the article by H.‐S. Chong et al. on p. 6641 ff.