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Selective Synthesis of New Fluorinated Alicyclic β‐Amino Ester Stereoisomers (Eur. J. Org. Chem. 26/2011)
Author(s) -
Kiss Loránd,
Forró Enikő,
Fustero Santos,
Fülöp Ferenc
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201190069
Subject(s) - alicyclic compound , chemistry , fluorine , hydroxylation , organic chemistry , stereochemistry , medicinal chemistry , enzyme
The cover picture shows a waterfall located in the Eastern Carpathians in Transylvania, near Bicaz Canyon. Although fluorinated organic compounds are nonexistent in nature, an increasing number of drugs (25 %) on the market contain at least one fluorine atom. Cyclic fluorinated β‐amino acid derivatives have been synthesized by selective hydroxylation and hydroxy?fluorine exchange. Details are discussed in the article by F. Fülöp et al. on p. 4993 ff.