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Graphical Abstract: Eur. J. Org. Chem. 8/2011
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201190017
Subject(s) - chemistry , natural product , scanning electron microscope , clostridium , electron micrographs , cover (algebra) , scaffold , total synthesis , antimicrobial , bacteria , combinatorial chemistry , stereochemistry , nanotechnology , microbiology and biotechnology , electron microscope , organic chemistry , biology , biomedical engineering , materials science , physics , engineering , optics , mechanical engineering , genetics
The cover picture shows the structure of closthioamide, the first example of secondary metabolites produced by anaerobic bacteria (see bottom, scanning‐electron micrograph of the natural producer Clostridium cellulolyticum ). The natural product exhibits high antimicrobial activity, in particular against resistant pathogens (MRSA and VRE, see background). Because closthioamide represents a novel drug scaffold and its availability is limited by low production rates in C. cellulolyticum cultures, we developed a highly efficient total synthesis involving convergent peptide coupling and polythionation. Details are discussed in the Short Communication by C. Hertweck et al. on p. 1429 ff. We thank Dr. S. Nietzsche (Electron Microscopy Centre of the University Hospital, Jena) for providing scanning‐electron micrographs and Nico Ueberschaar for graphical processing.