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Stereocontrolled Synthesis of the cis ‐Hydroxydecalin System: Towards Biologically Active 19‐ nor ‐Clerodanes
Author(s) -
Mirzayans Paul Malek,
Pouwer Rebecca H.,
Williams Craig M.,
Bernhardt Paul V.
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101807
Subject(s) - decalin , chemistry , stereochemistry , scaffold , combinatorial chemistry , core (optical fiber) , organic chemistry , catalysis , computer science , programming language , telecommunications
The 19‐ nor ‐clerodanes are compact, densely functionalized diterpenes based on a stereocentre‐rich decalin scaffold. To date only a few examples of the 19‐ nor ‐clerodanes have been synthesized, hence new flexible strategies are required. We herein describe the stereocontrolled construction of the cis ‐hydroxy decalin core in a concise fashion.