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Solvent‐Free Tandem Synthesis of 2‐Thiazolines and 2‐Oxazolines Catalyzed by a Copper Catalyst
Author(s) -
Li Xiangnan,
Zhou Baoyue,
Zhang Jin,
She Mengyao,
An Shujuan,
Ge Haixia,
Li Cong,
Yin Bing,
Li Jianli,
Shi Zhen
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101786
Subject(s) - chemistry , catalysis , tandem , selectivity , copper , hydrochloride , solvent , organic chemistry , methacrylate , reaction conditions , combinatorial chemistry , polymer , copolymer , composite material , materials science
Tandem reactions of nitriles with 2‐aminoethanethiol hydrochloride or amino alcohols in the presence of a catalytic amount of cupric methacrylate (Cu II 2 L 4 , L = methacrylate) were employed to prepare 2‐thiazolines and 2‐oxazolines under mild reaction conditions. The synthetic procedure showed high selectivity for the synthesis of mono‐ and bis‐thiazolines and oxazolines, and a variety of 2‐thiazolines and 2‐oxazolines was obtained in good to excellent yields.