Solvent‐Free Tandem Synthesis of 2‐Thiazolines and 2‐Oxazolines Catalyzed by a Copper Catalyst | Zendy

Li Xiangnan | Zendy; Zhou Baoyue | Zendy; Zhang Jin | Zendy; She Mengyao | Zendy; An Shujuan | Zendy; Ge Haixia | Zendy; Li Cong | Zendy; Yin Bing | Zendy; Li Jianli | Zendy; Shi Zhen | Zendy

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Solvent‐Free Tandem Synthesis of 2‐Thiazolines and 2‐Oxazolines Catalyzed by a Copper Catalyst

Author(s) -

Li Xiangnan,

Zhou Baoyue,

Zhang Jin,

She Mengyao,

An Shujuan,

Ge Haixia,

Li Cong,

Yin Bing,

Li Jianli,

Shi Zhen

Publication year - 2012

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201101786

Subject(s) - chemistry , catalysis , tandem , selectivity , copper , hydrochloride , solvent , organic chemistry , methacrylate , reaction conditions , combinatorial chemistry , polymer , copolymer , composite material , materials science

Tandem reactions of nitriles with 2‐aminoethanethiol hydrochloride or amino alcohols in the presence of a catalytic amount of cupric methacrylate (Cu II 2 L 4 , L = methacrylate) were employed to prepare 2‐thiazolines and 2‐oxazolines under mild reaction conditions. The synthetic procedure showed high selectivity for the synthesis of mono‐ and bis‐thiazolines and oxazolines, and a variety of 2‐thiazolines and 2‐oxazolines was obtained in good to excellent yields.

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