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Synthesis of Modified Phenylalanine Peptides by Cross Enyne Metathesis and a Diels–Alder Reaction as Key Steps
Author(s) -
Kotha Sambasivarao,
Goyal née Bansal Deepti,
Thota Niranjan,
Srinivas Venu
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101744
Subject(s) - chemistry , enyne metathesis , tripeptide , diels–alder reaction , metathesis , enyne , peptide , salt metathesis reaction , phenylalanine , organic chemistry , combinatorial chemistry , stereochemistry , amino acid , catalysis , biochemistry , polymerization , polymer
Modified phenylalanine‐based di‐ and tripeptides have been efficiently assembled by cross enyne metathesis and a Diels–Alder reaction as key steps under mild conditions. In all cases, peptide integrity was preserved, no racemisation was observed, and good yields of modified peptides were obtained.

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