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Synthesis of Spiro[indoline‐3,2′‐quinoline] Derivatives through a Four‐Component Reaction
Author(s) -
Sun Jing,
Sun Yan,
Gao Hong,
Yan ChaoGuo
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101737
Subject(s) - indoline , chemistry , quinoline , multi component reaction , isatin , acetylenedicarboxylate , dimethyl acetylenedicarboxylate , cyclohexane , component (thermodynamics) , acetic acid , organic chemistry , isoquinoline , combinatorial chemistry , catalysis , cycloaddition , physics , thermodynamics
Abstract An efficient synthetic procedure for the synthesis of functionalized tetrahydrospiro[indoline‐3,2′‐quinoline] derivatives was successfully developed and involves the four‐component reaction of arylamines, dimethyl acetylenedicarboxylate, isatins, and a cyclohexane‐1,3‐dione in acetic acid. The advantages of this reaction include the use of common starting materials and mild reaction conditions and it is operationally simple.