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Development of Microwave‐Assisted Reactions for PAMAM Dendrimer Synthesis
Author(s) -
LópezAndarias Javier,
Guerra Javier,
Castañeda Gregorio,
Merino Sonia,
Ceña Valentín,
SánchezVerdú Prado
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101717
Subject(s) - dendrimer , chemistry , regioselectivity , capillary electrophoresis , microwave chemistry , nuclear magnetic resonance spectroscopy , microwave , mass spectrometry , microwave irradiation , combinatorial chemistry , chromatography , polymer chemistry , organic chemistry , catalysis , physics , quantum mechanics
PAMAM dendrimers up to G1 have been synthesized by the divergent method taking advantage of microwave irradiation and using the CoolMate TM accessory to avoid high temperatures and long reaction times, which usually lead to defects in the dendrimer structure. Two tools have been successfully used to determine the purity of the products in addition to NMR spectroscopy, namely MALDI‐TOF mass spectrometry and capillary‐zone electrophoresis. These techniques show that the dendrimers were obtained in good yields, high purity, and with near‐perfect regioselectivity.