Direct Base‐Assisted C–N Bond Formation between Aryl Halides and Aliphatic Tertiary Amines under Transition‐Metal‐Free Conditions | Zendy

Fang Yang | Zendy; Zheng Yueqin | Zendy; Wang Zhiyong | Zendy

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Direct Base‐Assisted C–N Bond Formation between Aryl Halides and Aliphatic Tertiary Amines under Transition‐Metal‐Free Conditions

Author(s) -

Fang Yang,

Zheng Yueqin,

Wang Zhiyong

Publication year - 2012

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201101618

Subject(s) - chemistry , halide , aryl , amination , tertiary amine , transition metal , organic chemistry , combinatorial chemistry , polymer chemistry , catalysis , alkyl

Direct base‐mediated amination of aryl halides with aliphatic tertiary amines via an aryne intermediate was developed under transition‐metal‐free conditions. This operationally simple C–N bond‐coupling protocol could tolerate a variety of functionalized aryl halides as well as several aliphatic tertiary amines. Moreover, this environmentally benign process provides a new strategy for direct C–N bond formation.

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