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Biosynthesis and Total Synthesis Studies on the Jadomycin Family of Natural Products
Author(s) -
Sharif Ehesan U.,
O'Doherty George A.
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101609
Subject(s) - chemistry , biosynthesis , total synthesis , natural (archaeology) , organic chemistry , stereochemistry , combinatorial chemistry , enzyme , archaeology , history
Jadomycins are unique angucycline polyketides produced by Streptomyces venezuelae soil bacteria under specific nutrient and environmental conditions. Their unique structural complexity and biological activities have engendered extensive study of the jadomycin class of natural compounds in terms of biological activity, biosynthesis, and synthesis. This review outlines recent developments in the study of the synthesis and biosynthesis of jadomycins.