A Carbohydrate‐Based Synthesis of the C13–C22 Fragment of Amphidinolide X | Zendy

Gurjar Mukund K. | Zendy; Yellol Gorakh S. | Zendy; Mohapatra Debendra K. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A Carbohydrate‐Based Synthesis of the C13–C22 Fragment of Amphidinolide X

Author(s) -

Gurjar Mukund K.,

Yellol Gorakh S.,

Mohapatra Debendra K.

Publication year - 2012

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201101605

Subject(s) - chemistry , tetrahydrofuran , wittig reaction , deoxygenation , stereochemistry , stereoselectivity , fragment (logic) , mitsunobu reaction , carbohydrate , total synthesis , combinatorial chemistry , organic chemistry , catalysis , algorithm , solvent , computer science

A facile carbohydrate‐based route was developed for the synthesis of the tetrahydrofuran (C13–C22) fragment of amphidinolide X. Starting from L ‐sorbose, the key reactions followed include the stereoselective synthesis of a quaternary center at C1, Barton–McCombie deoxygenation at C2, Mitsunobu inversion at C3, and chain elongation by a Wittig reaction at C5.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research