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Tandem Reactions Leading to Benzo[ c ]chromen‐6‐ones and 3‐Substituted Isocoumarins
Author(s) -
Fan Xuesen,
He Yan,
Cui Liangyan,
Guo Shenghai,
Wang Jianji,
Zhang Xinying
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101559
Subject(s) - isocoumarins , chemistry , tandem , stereochemistry , combinatorial chemistry , catalysis , organic chemistry , materials science , composite material
A simple and convenient protocol for the synthesis of benzo[ c ]chromen‐6‐ones and 3‐substituted isocoumarins through a Cu I ‐catalyzed tandem reaction of 2‐bromobenzoates withcyclohexane‐1,3‐diones or acyclic 1,3‐diones is developed. This strategy can also be extended to the one‐pot synthesis of isoquinolin‐1(2 H )‐one and 3,4‐dihydrophenanthridine‐1,6(2 H ,5 H )‐dione.