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An Improved Copper‐Mediated Oxidative Trifluoromethylation of Terminal Alkynes
Author(s) -
Zhang Ke,
Qiu XiaoLong,
Huang Yangen,
Qing FengLing
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101550
Subject(s) - trifluoromethylation , chemistry , copper , oxidative phosphorylation , aryl , combinatorial chemistry , terminal (telecommunication) , organic chemistry , trifluoromethyl , biochemistry , telecommunications , alkyl , computer science
An improved method for the efficient copper‐mediated trifluoromethylation of terminal alkynes has been developed. This protocol highlights the convenient access to a variety of aryl‐substituted trifluoromethylated alkynes by oxidative trifluoromethylation with two equivalents of TMSCF 3 at room temperature.