Copper‐Mediated C–H Activation of 1,3,4‐Oxadiazoles with 1,1‐Dibromo‐1‐alkenes Using PEG‐400 as a Solvent Medium: Distinct Approach for the Alkynylation of 1,3,4‐Oxadiazoles | Zendy

Reddy Gandolla Chinna | Zendy; Balasubramanyam Penagaluri | Zendy; Salvan. | Zendy; Das Biswanath | Zendy

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Copper‐Mediated C–H Activation of 1,3,4‐Oxadiazoles with 1,1‐Dibromo‐1‐alkenes Using PEG‐400 as a Solvent Medium: Distinct Approach for the Alkynylation of 1,3,4‐Oxadiazoles

Author(s) -

Reddy Gandolla Chinna,

Balasubramanyam Penagaluri,

Salvan.,

Das Biswanath

Publication year - 2012

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201101542

Subject(s) - chemistry , alkynylation , solvent , ligand (biochemistry) , peg ratio , copper , medicinal chemistry , organic chemistry , combinatorial chemistry , stereochemistry , catalysis , biochemistry , receptor , finance , economics

The direct C–H alkynylation of 1,3,4‐oxadiazoles with 1,1‐dibromo‐1‐alkenes has been accomplished by using a combination of CuBr/LiO t Bu in PEG‐400 (a green solvent) at 80 °C. The products were formed in high yields (73–86 %) in 2 h. No additional ligand or volatile solvent was required and the conversion was ecofriendly.

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