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Copper‐Mediated C–H Activation of 1,3,4‐Oxadiazoles with 1,1‐Dibromo‐1‐alkenes Using PEG‐400 as a Solvent Medium: Distinct Approach for the Alkynylation of 1,3,4‐Oxadiazoles
Author(s) -
Reddy Gandolla Chinna,
Balasubramanyam Penagaluri,
Salvan.,
Das Biswanath
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101542
Subject(s) - chemistry , alkynylation , solvent , ligand (biochemistry) , peg ratio , copper , medicinal chemistry , organic chemistry , combinatorial chemistry , stereochemistry , catalysis , biochemistry , receptor , finance , economics
The direct C–H alkynylation of 1,3,4‐oxadiazoles with 1,1‐dibromo‐1‐alkenes has been accomplished by using a combination of CuBr/LiO t Bu in PEG‐400 (a green solvent) at 80 °C. The products were formed in high yields (73–86 %) in 2 h. No additional ligand or volatile solvent was required and the conversion was ecofriendly.