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Total Synthesis of Indolizidine (+)‐223A
Author(s) -
Fellah Mouloud,
Lhommet Gérard,
MourièsMansuy Virginie
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101530
Subject(s) - indolizidine , chemistry , yield (engineering) , total synthesis , stereochemistry , materials science , metallurgy , alkaloid
We described the diastereoselective total synthesis of indolizidine (+)‐223A in 10 % overall yield over 14 steps starting from 6‐chlorohex‐2‐ynoate. Our strategy involved chain elongation through aldolization, the formation of the indolizidine skeleton by cyclization, and stereocontrolled hydrogenation.