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Nonenzymatic Acylative Kinetic Resolution of Racemic Amines and Related Compounds
Author(s) -
Krasnov Victor P.,
Gruzdev Dmitry A.,
Levit Galina L.
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101489
Subject(s) - kinetic resolution , chemistry , catalysis , resolution (logic) , organic chemistry , combinatorial chemistry , chiral resolution , enantioselective synthesis , enantiomer , artificial intelligence , computer science
Acylative kinetic resolution of racemic amines occupies a highly important place among the methods for preparation of enantio enriched or pure amines. Nonenzymatic acylative kinetic resolution is usually carried out in the presence of chiral acyl‐transfer catalysts or under the action of chiral enantio‐ or diastereoselective resolving agents. Recently, this line of investigations has been rapidly developed and very interesting results of design and synthetic application of both new catalysts and chiral acylating agents have been obtained. This microreview summarizes the recent advances in this area.