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Tethered Aminohydroxylation Reaction and Its Application to Total Synthesis
Author(s) -
Donohoe Timothy J.,
Callens Cedric K. A.,
Lacy Adam R.,
Winter Christian
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101464
Subject(s) - chemistry , generality , total synthesis , combinatorial chemistry , organic chemistry , psychology , psychotherapist
This review highlights key aspects of the Tethered Aminohydroxylation from its discovery to its current incarnation, which employs N , O ‐acylated derivatives as reoxidants for osmium. The potential and generality of this reaction has been demonstrated by its application in the synthesis of several natural products.