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Direct Arylation under Catalysis of an Oxime‐Derived Palladacycle: Search for a Phosphane‐Free Method
Author(s) -
Zhang Guofu,
Zhao Xiaobao,
Yan Yunbing,
Ding Chengrong
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101400
Subject(s) - chemistry , phenanthridine , benzothiazole , oxime , catalysis , intramolecular force , aryl , combinatorial chemistry , cycloisomerization , organic chemistry , alkyl
Abstract A phosphane‐free method for the direct arylation of benzothiazole by employing oxime‐derived palladacycle 1 as a catalyst was developed. The new catalyst system can be used for 2‐arylations by using aryl bromides and iodides. In addition, this method is especially suitable for the intramolecular direct coupling of bromo‐ and iodoamides, as well aschloroamides, to achieve a rapid synthesis of benzo[ c ]phenanthridine alkaloids.