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Synthesis of α,β‐Diketotriazoles by Aerobic Copper‐Catalyzed Oxygenation with Triazole as an Intramolecular Assisting Group
Author(s) -
Menendez Christophe,
Gau Sylvain,
Ladeira Sonia,
Lherbet Christian,
Baltas Michel
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101346
Subject(s) - chemistry , copper , intramolecular force , catalysis , triazole , group (periodic table) , oxygenation , medicinal chemistry , phenanthroline , combinatorial chemistry , polymer chemistry , photochemistry , organic chemistry , anesthesia , medicine
The catalytic oxidation of α‐ketotriazoles to α,β‐diketotriazoles was performed with CuCl 2 or CuI/2,9‐dimethyl‐1,10‐phenanthroline in air at 80 °C in good yields. Studies showed that the triazole group participates in complexation to the copper and favors oxidation.