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1‐(Trifluoromethyl)cyclopent‐3‐enecarboxylic Acid Derivatives: Platforms for Bifunctional Cyclic Trifluoromethyl Building Blocks
Author(s) -
Grellepois Fabienne,
Kikelj Vincent,
Coia Nicolas,
Portella Charles
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101321
Subject(s) - trifluoromethyl , chemistry , bifunctional , carboxylic acid , organic chemistry , combinatorial chemistry , catalysis , alkyl
We report herein the synthesis and applications of 1‐(trifluoromethyl)cyclopent‐3‐ene‐1‐carboxylic acid and itsesters, promising new trifluoromethylated cyclic building blocks. Initially prepared starting from a pentafluorodithiopropanoic ester, a more convenient and effective approach has been developed starting from commercially available trifluoropropanoic acid or its methyl ester. The interest in these building blocks is exemplified by their use as platforms for a variety of difunctional trifluoromethylcyclopentane derivatives.