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Synthesis of Triazole‐Epothilones by Using Cu 2 O Nanoparticles to Catalyze 1,3‐Dipolar Cycloaddition
Author(s) -
Duan Xiyan,
Zhang Yan,
Ding Yahui,
Lin Jianping,
Kong Xianglei,
Zhang Quan,
Dong Changming,
Luo Guoan,
Chen Yue
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101306
Subject(s) - chemistry , cycloaddition , epothilones , triazole , ring (chemistry) , 1,3 dipolar cycloaddition , click chemistry , combinatorial chemistry , stereochemistry , nanoparticle , organic chemistry , nanotechnology , catalysis , materials science
We report the total synthesis of a triazole‐epothilone analogue 1 . The key step to generate the macrocyclic ring and the triazole ring was to apply Cu 2 O nanoparticles (Cu 2 O‐NPs) to catalyze the 1,3‐dipolar cycloaddition. The conformation of 1 and its bioactivity in MCF cancer cell lines were investigated.