Synthesis of Triazole‐Epothilones by Using Cu 2 O Nanoparticles to Catalyze 1,3‐Dipolar Cycloaddition | Zendy

Duan Xiyan | Zendy; Zhang Yan | Zendy; Ding Yahui | Zendy; Lin Jianping | Zendy; Kong Xianglei | Zendy; Zhang Quan | Zendy; Dong Changming | Zendy; Luo Guoan | Zendy; Chen Yue | Zendy

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Synthesis of Triazole‐Epothilones by Using Cu 2 O Nanoparticles to Catalyze 1,3‐Dipolar Cycloaddition

Author(s) -

Duan Xiyan,

Zhang Yan,

Ding Yahui,

Lin Jianping,

Kong Xianglei,

Zhang Quan,

Dong Changming,

Luo Guoan,

Chen Yue

Publication year - 2012

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201101306

Subject(s) - chemistry , cycloaddition , epothilones , triazole , ring (chemistry) , 1,3 dipolar cycloaddition , click chemistry , combinatorial chemistry , stereochemistry , nanoparticle , organic chemistry , nanotechnology , catalysis , materials science

We report the total synthesis of a triazole‐epothilone analogue 1 . The key step to generate the macrocyclic ring and the triazole ring was to apply Cu 2 O nanoparticles (Cu 2 O‐NPs) to catalyze the 1,3‐dipolar cycloaddition. The conformation of 1 and its bioactivity in MCF cancer cell lines were investigated.

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