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The Development of Domino Reactions Incorporating the Heck Reaction: The Formation of N‐Heterocycles
Author(s) -
Rixson James E.,
Chaloner Thomas,
Heath Charles H.,
Tietze Lutz F.,
Stewart Scott G.
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101305
Subject(s) - domino , heck reaction , chemistry , cascade reaction , palladium , substrate (aquarium) , catalysis , combinatorial chemistry , ring (chemistry) , organic chemistry , oceanography , geology
The methodological development of a series of domino or cascade reactions affording a series of N‐heterocycles is described. The rapid formation of these ring systems is in each case associated with the incorporation of a Heck reaction at either an early or a late stage of the domino process. A range of catalytic conditions and substrate modifications for optimisation of domino Tsuji–Trost/Heck, Buchwald–Hartwig/Heck and Heck/carbopalladation reaction sequences are reported.