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Catalytic Enantioselective Addition of MeMgBr and Other Grignard Reagents to Aldehydes
Author(s) -
FernándezMateos Emilio,
Maciá Beatriz,
Ramón Diego J.,
Yus Miguel
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101283
Subject(s) - enantioselective synthesis , chemistry , reagent , catalysis , organic chemistry , aldehyde , grignard reagent , combinatorial chemistry , reaction conditions
Herein, we report an efficient catalyst for the challenging enantioselective addition of MeMgBr to aldehydes. Unprecedented yields and enantioselectivities are achieved in the reaction with a broad range of aldehydes. Moreover, a variety of Grignard reagents can be also added to aromatic and aliphatic aldehydes in good yields and enantioselectivities in a simple one‐pot procedure under mild conditions.