Catalytic Enantioselective Addition of MeMgBr and Other Grignard Reagents to Aldehydes | Zendy

FernándezMateos Emilio | Zendy; Maciá Beatriz | Zendy; Ramón Diego J. | Zendy; Yus Miguel | Zendy

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Catalytic Enantioselective Addition of MeMgBr and Other Grignard Reagents to Aldehydes

Author(s) -

FernándezMateos Emilio,

Maciá Beatriz,

Ramón Diego J.,

Yus Miguel

Publication year - 2011

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201101283

Subject(s) - enantioselective synthesis , chemistry , reagent , catalysis , organic chemistry , aldehyde , grignard reagent , combinatorial chemistry , reaction conditions

Herein, we report an efficient catalyst for the challenging enantioselective addition of MeMgBr to aldehydes. Unprecedented yields and enantioselectivities are achieved in the reaction with a broad range of aldehydes. Moreover, a variety of Grignard reagents can be also added to aromatic and aliphatic aldehydes in good yields and enantioselectivities in a simple one‐pot procedure under mild conditions.

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