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Total Synthesis of the Proposed Structure of Trocheliophorolide D
Author(s) -
Hwang Soonho,
Kim Jae Hyun,
Kim Hak Sung,
Kim Sanghee
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101209
Subject(s) - chemistry , aldol reaction , butenolide , moiety , natural product , stereochemistry , total synthesis , combinatorial chemistry , organic chemistry , catalysis
The proposed structure of trocheliophorolide D was synthesized, and the NMR spectra of the synthetic compound proved to be inconsistent with those of the natural product. Our synthesis features the construction of the 2‐butenolide moiety by using an aldol strategy and assembly of the triyne system during the final stage of the synthesis.