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Application of Proline‐Functionalised 1,2‐Diphenylethane‐1,2‐diamine (DPEN) in Asymmetric Transfer Hydrogenation of Ketones
Author(s) -
Manville Charles V.,
Docherty Gordon,
Padda Ranbir,
Wills Martin
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101164
Subject(s) - chemistry , transfer hydrogenation , diamine , proline , organic chemistry , asymmetric hydrogenation , noyori asymmetric hydrogenation , enantioselective synthesis , catalysis , amino acid , biochemistry , ruthenium
A series of enantiomerically pure ligands containing a combination of proline and DPEN groups have been prepared and employed in the asymmetric transfer hydrogenation of ketones. In the case of cyclic ketones, alcohols with ee values of up to 98 % were obtained.