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Dienamine Catalysis: An Emerging Technology in Organic Synthesis
Author(s) -
Ramachary Dhevalapally B.,
Reddy Y. Vijayendar
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101157
Subject(s) - enantioselective synthesis , chemistry , enamine , catalysis , atom economy , organocatalysis , environmentally friendly , combinatorial chemistry , organic synthesis , nanotechnology , molecule , total synthesis , chemical reaction engineering , biochemical engineering , organic chemistry , ecology , materials science , engineering , biology
High‐yielding asymmetric synthesis of bioactive molecules with the aid of mild catalysis is an efficient approach in reaction engineering. In the early days, synthetic chemists mainly focused on the synthesis of complex molecules, but not much on reaction efficiency and eco‐friendly conditions. Recent investigations have been directed towards the development of atom economy and of eco‐friendly and enantioselective synthesis in the most efficient ways. In this regard, the development of newly emerging asymmetric enamine and dienamine catalysis shows one way in which a powerful technology can address these critical issues. Here we discuss the entire saga of dienamine chemistry from “preformed dienamines” to “in situ dienamines” and its applications in the synthesis of bioactive molecules and natural products.