Synthesis of the Indolic Pentacyclic Core of Manadomanzamine A Following Biogenetically Based Strategies | Zendy

Yan LokHang | Zendy; Nuhant Philippe | Zendy; Sinigaglia Isabelle | Zendy; Fromentin Yann | Zendy; Marazano Christian | Zendy; Delpech Bernard | Zendy; Poupon Erwan | Zendy

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Synthesis of the Indolic Pentacyclic Core of Manadomanzamine A Following Biogenetically Based Strategies

Author(s) -

Yan LokHang,

Nuhant Philippe,

Sinigaglia Isabelle,

Fromentin Yann,

Marazano Christian,

Delpech Bernard,

Poupon Erwan

Publication year - 2012

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201101133

Subject(s) - chemistry , biomimetic synthesis , sponge , alkaloid , indole test , stereochemistry , indole alkaloid , organic chemistry , botany , biology

Manadomanzamine A is a complex alkaloid isolated from a marine sponge that shows promising biological activities. A biosynthetic hypothesis is proposed and is used as a guideline for biomimetic approaches to the pentacyclic indole nucleus of manadomanzamine A. The rich chemistry of reactive C 5 units such as glutaconaldehydes or aminopentadienals was exploited towards this end.

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