Premium
A Mild Titanium‐Catalyzed Synthesis of Functionalized Amino Coumarins as Fluorescence Labels
Author(s) -
Wirtz Lisa,
Kazmaier Uli
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101117
Subject(s) - chemistry , fluorescence , catalysis , combinatorial chemistry , lewis acids and bases , coumarin , condensation , amino acid , titanium , organic chemistry , biochemistry , physics , quantum mechanics , thermodynamics
In contrast to Brønsted and other Lewis acids ClTi(O i Pr) 3 is especially suited to catalyze the formation of amino‐substituted coumarins from aminophenols and functionalized β‐oxo esters in a Pechmann condensation. This straightforward protocol allows the synthesis of fluorescence labels and false fluorescent neurotransmitters.