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Organocatalyzed Cascade Reactions of Cyclic β‐Enamino Esters and α,β‐Unsaturated Aldehydes Leading to Indoloquinolizidines and Benzoquinolizidines
Author(s) -
Wu Xiaoyu,
Nie Linlin,
Fang Huihui,
Chen Jie,
Cao Weiguo,
Zhao Gang
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101105
Subject(s) - chemistry , organic chemistry , cascade , cascade reaction , catalysis , chromatography
Organocatalyzed cascade reactions between cyclic β‐enamino esters and α,β‐unsaturated aldehydes have been developed. They provide highly substituted indolo[2,3‐ a ]quinolizidines and benzo[ a ]quinolizidines in moderate to good yields and with good to excellent enantioselectivities. Both aromatic and aliphatic α,β‐unsaturated aldehydes react readily with enamino esters to furnish the desired products.