Tandem Amination/Cycloisomerization of Aryl Propargylic Alcohols with 2‐Aminopyridines as an Expedient Route to Imidazo[1,2‐ a ]pyridines | Zendy

Liu Ping | Zendy; Deng ChunLin | Zendy; Lei Xinsheng | Zendy; Lin Guoqiang | Zendy

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Tandem Amination/Cycloisomerization of Aryl Propargylic Alcohols with 2‐Aminopyridines as an Expedient Route to Imidazo[1,2‐ a ]pyridines

Author(s) -

Liu Ping,

Deng ChunLin,

Lei Xinsheng,

Lin Guoqiang

Publication year - 2011

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201101053

Subject(s) - aminopyridines , chemistry , cycloisomerization , tandem , amination , intramolecular force , aryl , combinatorial chemistry , cascade reaction , organic chemistry , medicinal chemistry , catalysis , materials science , alkyl , composite material

A new tandem route leading to imidazo[1,2‐ a ]pyridines has been explored through the direct amination of aryl propargylic alcohols with 2‐aminopyridines and their subsequent intramolecular cycloisomerization. A ZnCl 2 /CuCl system has been developed to promote this transformation, which resulted in various imidazo[1,2‐ a ]pyridines in moderate to good yields.

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