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Tandem Amination/Cycloisomerization of Aryl Propargylic Alcohols with 2‐Aminopyridines as an Expedient Route to Imidazo[1,2‐ a ]pyridines
Author(s) -
Liu Ping,
Deng ChunLin,
Lei Xinsheng,
Lin Guoqiang
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101053
Subject(s) - aminopyridines , chemistry , cycloisomerization , tandem , amination , intramolecular force , aryl , combinatorial chemistry , cascade reaction , organic chemistry , medicinal chemistry , catalysis , materials science , alkyl , composite material
A new tandem route leading to imidazo[1,2‐ a ]pyridines has been explored through the direct amination of aryl propargylic alcohols with 2‐aminopyridines and their subsequent intramolecular cycloisomerization. A ZnCl 2 /CuCl system has been developed to promote this transformation, which resulted in various imidazo[1,2‐ a ]pyridines in moderate to good yields.