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Microwave‐Assisted Synthesis of Polysubstituted Benzimidazoles by Heterogeneous Pd‐Catalyzed Oxidative C–H Activation of Tertiary Amines
Author(s) -
De Luca Lidia,
Porcheddu Andrea
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201101001
Subject(s) - chemistry , catalysis , oxidative phosphorylation , alkene , tertiary amine , organic chemistry , combinatorial chemistry , amine gas treating , microwave heating , heterogeneous catalysis , microwave chemistry , microwave , microwave irradiation , biochemistry , physics , quantum mechanics
Abstract Tertiary amines can be used in place of aldehydes and carboxylic derivatives as partners in the synthesis of benzimidazoles. Dehydrogenative amine activation under heterogeneous catalysis was developed for the direct transformation of tertiary amines into benzimidazoles. Good yields and efficient recovery and recycling of the catalyst are some of the advantages of this new methodology, which shows that a simple alkene is used as the overall oxidative agent. Enhanced reaction rates were observed by using focused microwave heating.