Synthesis of New Dopamine D1 Antagonist SCH 23390 Analogues by the Stereoselective Stevens Rearrangement | Zendy

Ariza Manuela | Zendy; Díaz Amelia | Zendy; Suau Rafael | Zendy; Valpuesta María | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of New Dopamine D1 Antagonist SCH 23390 Analogues by the Stereoselective Stevens Rearrangement

Author(s) -

Ariza Manuela,

Díaz Amelia,

Suau Rafael,

Valpuesta María

Publication year - 2011

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201100991

Subject(s) - chemistry , sch 23390 , stereoselectivity , stereochemistry , benzazepines , alkylation , combinatorial chemistry , antagonist , organic chemistry , catalysis , biochemistry , receptor

A convenient synthesis for new SCH 23390 analogues bearing different substituents at the C‐1 position has been developed by using the diastereoselective Stevens rearrangement. This procedure has provided a good number of new 1,2‐disubstituted 1 H ‐3‐benzazepines, either through isolation of the isoquinolinium salts or directly by using a new one‐pot N ‐alkylation–Stevens rearrangement reaction.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research