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Metal‐Free Oxidative Coupling Reactions via σ‐Iodonium Intermediates: The Efficient Synthesis of Bithiophenes Using Hypervalent Iodine Reagents
Author(s) -
Morimoto Koji,
Nakae Tomofumi,
Yamaoka Nobutaka,
Dohi Toshifumi,
Kita Yasuyuki
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100969
Subject(s) - hypervalent molecule , chemistry , reagent , iodine , oxidative coupling of methane , reactivity (psychology) , coupling reaction , combinatorial chemistry , reaction mechanism , photochemistry , organic chemistry , catalysis , alternative medicine , pathology , medicine
The direct oxidative biaryl coupling reaction is an attractive tool for environmentally benign green chemistry. A novel direct method for the synthesis of bithiophene using a hypervalent iodine reagent has been developed. The reaction mechanism has also been investigated, casting light on the reaction intermediate and revealing the reactivity with iodonium salts.