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Phosphite‐Mediated Synthesis of Benzimidazoles: A One‐Pot Four‐Component Approach from Nitrophenols
Author(s) -
El Kaïm Laurent,
Grimaud Laurence,
Purumandla Srinivas Reddy
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100939
Subject(s) - chemistry , yield (engineering) , nitroso , component (thermodynamics) , benzimidazole , organic chemistry , combinatorial chemistry , medicinal chemistry , materials science , physics , metallurgy , thermodynamics
Benzimidazoles may be formed in high yield through the phosphite‐triggered reductive cyclization of o ‐nitroaniline derivatives. This reaction was used for the one‐pot synthesis of benzimidazoles from o ‐nitrophenols and isocyanides. The mechanism is discussed in relation with nitroso intermediates.