Enantioselective Synthesis of 2‐Substituted‐1,5‐Benzodiazepines through Domino Reaction of  o ‐Phenylenediamine and Chalcone Derivatives | Zendy

Fu Xuan | Zendy; Feng Juhua | Zendy; Dong Zhenhua | Zendy; Lin Lili | Zendy; Liu Xiaohua | Zendy; Feng Xiaoming | Zendy

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Enantioselective Synthesis of 2‐Substituted‐1,5‐Benzodiazepines through Domino Reaction of o ‐Phenylenediamine and Chalcone Derivatives

Author(s) -

Fu Xuan,

Feng Juhua,

Dong Zhenhua,

Lin Lili,

Liu Xiaohua,

Feng Xiaoming

Publication year - 2011

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201100938

Subject(s) - enantioselective synthesis , chemistry , chalcone , domino , o phenylenediamine , ligand (biochemistry) , medicinal chemistry , organic chemistry , stereochemistry , combinatorial chemistry , catalysis , biochemistry , receptor

Chiral 2‐substituted‐1,5‐benzodiazepine derivatives were synthesized for the first time from an enantioselective domino reaction involving o ‐phenylenediamine and 2′‐hydroxychalcones. The titanium complex formed from chiral ligand 1a derived from ( S )‐BINOL and L ‐prolineamide promoted the reaction and gave the products in good yields with up to 82 % ee .

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