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Synthesis of Biaryls by Pd‐Catalyzed Decarboxylative Homo‐ and Heterocoupling of Substituted Benzoic Acids
Author(s) -
Xie Kai,
Wang Sizhuo,
Yang Zhiyong,
Liu Jidan,
Wang Anwei,
Li Xiujian,
Tan Ze,
Guo CanCheng,
Deng Wei
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100913
Subject(s) - chemistry , catalysis , yield (engineering) , benzoic acid , nitro , substrate (aquarium) , base (topology) , decarboxylation , organic chemistry , medicinal chemistry , combinatorial chemistry , mathematical analysis , alkyl , materials science , oceanography , mathematics , metallurgy , geology
By carefully choosing the right substrate ratio, catalyst combination, and base, symmetrical and unsymmetrical biaryls can be readily synthesized through the Pd‐catalyzed decarboxylative homo‐ and heterocoupling of substituted benzoic acids. The reaction gave the desired products in 40–90 % yield and is compatible with 2‐nitro‐, 2‐methoxy‐, 2‐fluoro‐, and 2‐chloro‐substituted benzoic acids.