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Transition‐Metal‐Mediated Routes to 3,3‐Disubstituted Oxindoles through Anilide Cyclisation
Author(s) -
Klein Johannes E. M. N.,
Taylor Richard J. K.
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100836
Subject(s) - chemistry , transition metal , combinatorial chemistry , palladium , natural product , heck reaction , organic chemistry , stereochemistry , catalysis
This review describes transition‐metal‐catalysed and ‐mediated processes for the preparation of oxindoles from anilides through C(3)–C(3a) bond formation. Traditional methods, such as the Heck reaction, and recent developments, including direct Ar–H coupling processes, are presented, as are applications in natural product synthesis.