Premium
Copper‐Catalyzed Domino One‐Pot Synthesis of 2‐(Arylselanyl)arylcyanamides
Author(s) -
Ramana Tamminana,
Punniyamurthy Tharmalingam
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100785
Subject(s) - chemistry , domino , aryl , copper , intermolecular force , yield (engineering) , catalysis , medicinal chemistry , coupling reaction , one pot synthesis , organic chemistry , polymer chemistry , combinatorial chemistry , molecule , alkyl , materials science , metallurgy
Domino C–Se cross‐coupling of 2‐(iodoaryl)selenoureas with aryl iodides has been accomplished in the presence of a copper(I)–1,1‐phenanthroline complex at moderate temperature. The reactions involve intra‐ and intermolecular C–Se cross‐coupling to give the substituted 2‐(arylselanyl)arylcyanamides. Aryl iodides having electron‐donating and ‐withdrawing substituents are compatible, affording the targetselanyl ethers in high yield.