Synthesis of 5‐Alkynyl Isoxazolidinyl Nucleosides | Zendy

Romeo Roberto | Zendy; Giofrè Salvatore Vincenzo | Zendy; Iaria Daniela | Zendy; Sciortino Maria Teresa | Zendy; Ronsisvalle Simone | Zendy; Chiacchio Maria Assunta | Zendy; Scala Angela | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of 5‐Alkynyl Isoxazolidinyl Nucleosides

Author(s) -

Romeo Roberto,

Giofrè Salvatore Vincenzo,

Iaria Daniela,

Sciortino Maria Teresa,

Ronsisvalle Simone,

Chiacchio Maria Assunta,

Scala Angela

Publication year - 2011

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201100767

Subject(s) - chemistry , sonogashira coupling , acetylene , cycloaddition , nucleoside , stereochemistry , palladium , alkyne , combinatorial chemistry , medicinal chemistry , catalysis , organic chemistry

Starting with 5‐iodo N,O‐nucleosides, prepared by 1,3‐dipolar cycloaddition of nitrones with vinyliodouracil, or vinyl acetate followed by coupling with silylated iodouracil, a series of 5‐alkynyl N,O‐nucleosides were synthesized via a palladium‐catalyzed (Sonogashira) coupling reaction. The cytotoxic activity of modified nucleosides against HEp‐2 cell lines was determined in vitro. The 5‐ethynyl N,O‐nucleoside, the only compound in the series containing a terminal acetylene unit, was found to be the most active compound.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research