Premium
Synthesis of Various Chiral 1,2,4‐Triazole‐Containing α‐Amino Acids from Aspartic or Glutamic Acids
Author(s) -
Blayo AnneLaure,
Brunel Frédéric,
Martinez Jean,
Fehrentz JeanAlain
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100611
Subject(s) - chemistry , moiety , amino acid , aspartic acid , triazole , stereochemistry , combinatorial chemistry , glutamic acid , peptide , side chain , organic chemistry , biochemistry , polymer
Starting from N‐ and C‐protected aspartic or glutamic acids, new unnatural α‐amino acids containing 3,4,5‐trisubstituted 1,2,4‐triazole heterocycles on their side chains have been synthesized. Two points of diversity could easily be achieved on the heterocyclic moiety, which could easily be incorporated in peptide sequences to modify or improve their pharmacokinetic properties.