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Cleistanone: A Triterpenoid from Cleistanthus indochinensis with a New Carbon Skeleton
Author(s) -
Thanh Van Trinh Thi,
Pham Van Cuong,
Nguyen Hung Huy,
Mai Huong Doan Thi,
Minh Hang Nguyen Thi,
Nguyen Van Hung,
Litaudon Marc,
Guéritte Françoise,
Chau Van Minh
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100505
Subject(s) - carbon skeleton , chemistry , triterpenoid , skeleton (computer programming) , stereochemistry , anatomy , biology
Cleistanone ( 1 ) was isolated from the leaves of Cleistanthus indochinensis and features a new type of triterpenoid carbon skeleton. Its structure was confirmed by X‐ray diffraction analysis. A plausible biosynthetic pathway was proposed for 1 and is thought to proceed through a Wagner–Meerwein rearrangement. Cleistanone ( 1 ) was found to show cytotoxic activity against human oral epidermoid carcinoma KB cells.