Novel Quinidine‐Derived Organocatalysts for the Asymmetric Substitutions of  O ‐Boc‐Protected Morita–Baylis–Hillman Adducts | Zendy

Pei ChengKui | Zendy; Zhang XiuChun | Zendy; Shi Min | Zendy

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Novel Quinidine‐Derived Organocatalysts for the Asymmetric Substitutions of O ‐Boc‐Protected Morita–Baylis–Hillman Adducts

Author(s) -

Pei ChengKui,

Zhang XiuChun,

Shi Min

Publication year - 2011

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201100501

Subject(s) - chemistry , adduct , yield (engineering) , baylis–hillman reaction , quinidine , organocatalysis , stereochemistry , enantioselective synthesis , stereocenter , organic chemistry , medicinal chemistry , catalysis , medicine , materials science , metallurgy , pharmacology

A series of novel quinidine‐derived organocatalysts was synthesized and utilized for the asymmetric substitution of O ‐Boc‐protected Morita–Baylis–Hillman adducts with various carbamates and tosylcarbamates, affording the corresponding products in good to high yields (up to 91 % yield) with moderate to high ee values (up to 96 % ee ) under mild conditions.

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