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A Synthetic Route to α‐Substituted Butenolides: Enantioselective Synthesis of (+)‐Ancepsenolide
Author(s) -
Ghobril Cynthia,
Kister Jérémy,
Baati Rachid
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100491
Subject(s) - butenolide , enantioselective synthesis , chemistry , total synthesis , organic chemistry , combinatorial chemistry , stereochemistry , lactone , catalysis
A variety of α‐substituted butenolides was efficiently synthesized starting from commercially available tetronic acid and carboxylic acids in four steps. The effectiveness of this approach is illustrated in the short synthesis of one of the first butenolide acetogenins: (+)‐ancepsenolide.